This study was conducted by Patience Onakurhefe, Fidelis I. Achuba and Betty O. George of Department of Biochemistry, Faculty of Science, Delta State University, Abraka, Nigeria with the aim of assessing different regimen of oil palm leaf extracts against crude oil-adulterated feed mediated nephrotoxicity.
The study comprised the use of different solvent extracts (aqueous, ethanol, methanol, acetone, petroleum ether) and blended mixtures of oil palm leaf to assess the efficacy against crude oil-imposed nephrotoxicity.
The regimen adopted were pre-treated, co-treated and post-treated with the plant extracts before, during and after exposure to crude oil-adulterated feed for 28 days of experimentation. All groups comprised six rats each.
The study results implicated crude oil polluted feed in the alteration of kidney function markers compared to positive control. It also increased levels of kidney lipid peroxidation and induced reduction in antioxidants: superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) relative to control. Treatment with oil palm leave extracts reversed these trends. The pre-treatment of animals with the various extracts was more efficient in handling the metabolic challenges compared to the co-treatment and post-treatment. However, different solvent extracts of oil palm leaves and blended solvent extracts of the leave had efficacy on the altered kidney dysfunction parameters.
The researchers concluded that; pretreatment of the animals with extracts, especially, the blended mixture exhibited more protective measure against crude oil-induced nephrotoxicity.