Development and evaluation of pediatric orally disintegrating paracetamol tablets

The limitations of commercially available paracetamol formulations specifically are its stability and portability and, non-pediatric friendly excipients and expensive manufacturing processes; which were addressed by developing tablets made using generally regarded as safe (GRAS) status excipients and a direct compression process. The aim of this study was to develop pediatric orally disintegrating tablets of paracetamol. Pediatric orally disintegrating tablets with 60-mg and 120-mg paracetamol strengths which disintegrated in less than 30 seconds were successfully prepared by a simple cost effective direct compression process. Tablet disintegration rates were found to correlate well with tablet water absorption ratios and to a lesser extent with tablet wetting times. There was no correlation between tablet disintegration times and tablet mechanical and physical properties such as the tablet breaking force (hardness) or friability.

Thank you for reading